7Z3P
Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution.
Summary for 7Z3P
Entry DOI | 10.2210/pdb7z3p/pdb |
Descriptor | Leptin, Leptin receptor, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | leptin, obesity, leptin receptor, lepr, adipose tissue, hypothalamus, immune system, cytokine |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 43525.42 |
Authors | Tsirigotaki, A.,Verschueren, K.,Savvides, S.N.,Verstraete, K. (deposition date: 2022-03-02, release date: 2023-03-22, Last modification date: 2024-02-07) |
Primary citation | Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.943 Å) |
Structure validation
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