7YXR
Crystal structure of mutant AncGR2-LBD (Y545A) bound to dexamethasone and SHP coregulator fragment
Summary for 7YXR
Entry DOI | 10.2210/pdb7yxr/pdb |
Descriptor | Ancestral Glucocorticoid Receptor2, SHP NR Box 1 Peptide, DEXAMETHASONE, ... (5 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, dexamethasone, mutant, nuclear protein |
Biological source | unidentified More |
Total number of polymer chains | 4 |
Total formula weight | 60878.79 |
Authors | Jimenez-Panizo, A.,Estebanez-Perpina, E.,Fuentes-Prior, P. (deposition date: 2022-02-16, release date: 2022-12-07, Last modification date: 2024-01-31) |
Primary citation | Jimenez-Panizo, A.,Alegre-Marti, A.,Tettey, T.T.,Fettweis, G.,Abella, M.,Anton, R.,Johnson, T.A.,Kim, S.,Schiltz, R.L.,Nunez-Barrios, I.,Font-Diaz, J.,Caelles, C.,Valledor, A.F.,Perez, P.,Rojas, A.M.,Fernandez-Recio, J.,Presman, D.M.,Hager, G.L.,Fuentes-Prior, P.,Estebanez-Perpina, E. The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities. Nucleic Acids Res., 50:13063-13082, 2022 Cited by PubMed: 36464162DOI: 10.1093/nar/gkac1119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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