7YXR
Crystal structure of mutant AncGR2-LBD (Y545A) bound to dexamethasone and SHP coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Ancestral Glucocorticoid Receptor2 | polymer | 249 | 28686.4 | 2 | UniProt (A0A1X8XLE9) Pfam (PF00104) In PDB | unidentified | |
| 2 | R, S | SHP NR Box 1 Peptide | polymer | 12 | 1291.5 | 2 | UniProt (Q15466) In PDB | Homo sapiens (Human) | Orphan nuclear receptor SHP,Small heterodimer partner,Nuclear receptor subfamily 0 group B member 2 |
| 3 | A, C | DEXAMETHASONE | non-polymer | 392.5 | 2 | Chemie (DEX) | |||
| 4 | C, S | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 5 | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A, C: 530 - 776 (UniProt: A0A1X8XLE9)
| PDB | External Database | Details |
|---|---|---|
| Glu 528 | - | expression tag |
| Phe 529 | - | expression tag |
| Ala 545 | Tyr 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59955.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 923.0 | |
| All* | Total formula weight | 60878.8 |
