7YV4

Crystal structure of human UCHL3 in complex with Farrerol

Summary for 7YV4

Entry DOI	10.2210/pdb7yv4/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase isozyme L3, (2~{S})-2-(4-hydroxyphenyl)-6,8-dimethyl-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one (3 entities in total)
Functional Keywords	activator, complex, ubiquitinase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	26513.88
Authors	Mao, Z.Y.,Xu, X.J.,Zhang, W.T. (deposition date: 2022-08-18, release date: 2023-04-19, Last modification date: 2023-11-29)
Primary citation	Zhang, W.,Wang, M.,Song, Z.,Fu, Q.,Chen, J.,Zhang, W.,Gao, S.,Sun, X.,Yang, G.,Zhang, Q.,Yang, J.,Tang, H.,Wang, H.,Kou, X.,Wang, H.,Mao, Z.,Xu, X.,Gao, S.,Jiang, Y. Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer. Nat Commun, 14:1838-1838, 2023 Cited by PubMed: 37012254 DOI: 10.1038/s41467-023-37576-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation