7X8X
structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
Summary for 7X8X
| Entry DOI | 10.2210/pdb7x8x/pdb |
| Descriptor | ATP-dependent Clp protease proteolytic subunit 2, ATP-dependent Clp protease proteolytic subunit 1, 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ... (4 entities in total) |
| Functional Keywords | antimicrobial agents, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Mycobacterium tuberculosis CDC1551 More |
| Total number of polymer chains | 56 |
| Total formula weight | 591966.23 |
| Authors | Bao, R.,Luo, Y.F.,Zhu, Y.B.,Yang, Y.,Zhou, Y.Z. (deposition date: 2022-03-15, release date: 2023-04-12, Last modification date: 2024-04-24) |
| Primary citation | Yang, Y.,Zhao, N.,Xu, X.,Zhou, Y.,Luo, B.,Zhang, J.,Sui, J.,Huang, J.,Qiu, Z.,Zhang, X.,Zeng, J.,Bai, L.,Bao, R.,Luo, Y. Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors J.Med.Chem., 66:16597-16614, 2023 Cited by DOI: 10.1021/acs.jmedchem.3c01054PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.24 Å) |
Structure validation
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