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7X8X

structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease

Functional Information from GO Data
ChainGOidnamespacecontents
A0004176molecular_functionATP-dependent peptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0008236molecular_functionserine-type peptidase activity
A0009274cellular_componentpeptidoglycan-based cell wall
A0009368cellular_componentendopeptidase Clp complex
A0051117molecular_functionATPase binding
B0004176molecular_functionATP-dependent peptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0006508biological_processproteolysis
C0004176molecular_functionATP-dependent peptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0008236molecular_functionserine-type peptidase activity
C0009274cellular_componentpeptidoglycan-based cell wall
C0009368cellular_componentendopeptidase Clp complex
C0051117molecular_functionATPase binding
D0004176molecular_functionATP-dependent peptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0006508biological_processproteolysis
E0004176molecular_functionATP-dependent peptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
E0008236molecular_functionserine-type peptidase activity
E0009274cellular_componentpeptidoglycan-based cell wall
E0009368cellular_componentendopeptidase Clp complex
E0051117molecular_functionATPase binding
F0004176molecular_functionATP-dependent peptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006508biological_processproteolysis
F0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
F0008236molecular_functionserine-type peptidase activity
F0009274cellular_componentpeptidoglycan-based cell wall
F0009368cellular_componentendopeptidase Clp complex
F0051117molecular_functionATPase binding
G0004176molecular_functionATP-dependent peptidase activity
G0004252molecular_functionserine-type endopeptidase activity
G0006508biological_processproteolysis
H0004176molecular_functionATP-dependent peptidase activity
H0004252molecular_functionserine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006508biological_processproteolysis
H0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
H0008236molecular_functionserine-type peptidase activity
H0009274cellular_componentpeptidoglycan-based cell wall
H0009368cellular_componentendopeptidase Clp complex
H0051117molecular_functionATPase binding
I0004176molecular_functionATP-dependent peptidase activity
I0004252molecular_functionserine-type endopeptidase activity
I0006508biological_processproteolysis
J0004176molecular_functionATP-dependent peptidase activity
J0004252molecular_functionserine-type endopeptidase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006508biological_processproteolysis
J0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
J0008236molecular_functionserine-type peptidase activity
J0009274cellular_componentpeptidoglycan-based cell wall
J0009368cellular_componentendopeptidase Clp complex
J0051117molecular_functionATPase binding
K0004176molecular_functionATP-dependent peptidase activity
K0004252molecular_functionserine-type endopeptidase activity
K0006508biological_processproteolysis
L0004176molecular_functionATP-dependent peptidase activity
L0004252molecular_functionserine-type endopeptidase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006508biological_processproteolysis
L0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
L0008236molecular_functionserine-type peptidase activity
L0009274cellular_componentpeptidoglycan-based cell wall
L0009368cellular_componentendopeptidase Clp complex
L0051117molecular_functionATPase binding
M0004176molecular_functionATP-dependent peptidase activity
M0004252molecular_functionserine-type endopeptidase activity
M0006508biological_processproteolysis
N0004176molecular_functionATP-dependent peptidase activity
N0004252molecular_functionserine-type endopeptidase activity
N0006508biological_processproteolysis
O0004176molecular_functionATP-dependent peptidase activity
O0004252molecular_functionserine-type endopeptidase activity
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0006508biological_processproteolysis
O0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
O0008236molecular_functionserine-type peptidase activity
O0009274cellular_componentpeptidoglycan-based cell wall
O0009368cellular_componentendopeptidase Clp complex
O0051117molecular_functionATPase binding
P0004176molecular_functionATP-dependent peptidase activity
P0004252molecular_functionserine-type endopeptidase activity
P0006508biological_processproteolysis
Q0004176molecular_functionATP-dependent peptidase activity
Q0004252molecular_functionserine-type endopeptidase activity
Q0005515molecular_functionprotein binding
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0006508biological_processproteolysis
Q0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
Q0008236molecular_functionserine-type peptidase activity
Q0009274cellular_componentpeptidoglycan-based cell wall
Q0009368cellular_componentendopeptidase Clp complex
Q0051117molecular_functionATPase binding
R0004176molecular_functionATP-dependent peptidase activity
R0004252molecular_functionserine-type endopeptidase activity
R0006508biological_processproteolysis
S0004176molecular_functionATP-dependent peptidase activity
S0004252molecular_functionserine-type endopeptidase activity
S0005515molecular_functionprotein binding
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0005886cellular_componentplasma membrane
S0006508biological_processproteolysis
S0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
S0008236molecular_functionserine-type peptidase activity
S0009274cellular_componentpeptidoglycan-based cell wall
S0009368cellular_componentendopeptidase Clp complex
S0051117molecular_functionATPase binding
T0004176molecular_functionATP-dependent peptidase activity
T0004252molecular_functionserine-type endopeptidase activity
T0005515molecular_functionprotein binding
T0005737cellular_componentcytoplasm
T0005829cellular_componentcytosol
T0005886cellular_componentplasma membrane
T0006508biological_processproteolysis
T0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
T0008236molecular_functionserine-type peptidase activity
T0009274cellular_componentpeptidoglycan-based cell wall
T0009368cellular_componentendopeptidase Clp complex
T0051117molecular_functionATPase binding
U0004176molecular_functionATP-dependent peptidase activity
U0004252molecular_functionserine-type endopeptidase activity
U0006508biological_processproteolysis
V0004176molecular_functionATP-dependent peptidase activity
V0004252molecular_functionserine-type endopeptidase activity
V0005515molecular_functionprotein binding
V0005737cellular_componentcytoplasm
V0005829cellular_componentcytosol
V0005886cellular_componentplasma membrane
V0006508biological_processproteolysis
V0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
V0008236molecular_functionserine-type peptidase activity
V0009274cellular_componentpeptidoglycan-based cell wall
V0009368cellular_componentendopeptidase Clp complex
V0051117molecular_functionATPase binding
W0004176molecular_functionATP-dependent peptidase activity
W0004252molecular_functionserine-type endopeptidase activity
W0006508biological_processproteolysis
X0004176molecular_functionATP-dependent peptidase activity
X0004252molecular_functionserine-type endopeptidase activity
X0005515molecular_functionprotein binding
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0005886cellular_componentplasma membrane
X0006508biological_processproteolysis
X0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
X0008236molecular_functionserine-type peptidase activity
X0009274cellular_componentpeptidoglycan-based cell wall
X0009368cellular_componentendopeptidase Clp complex
X0051117molecular_functionATPase binding
Y0004176molecular_functionATP-dependent peptidase activity
Y0004252molecular_functionserine-type endopeptidase activity
Y0006508biological_processproteolysis
Z0004176molecular_functionATP-dependent peptidase activity
Z0004252molecular_functionserine-type endopeptidase activity
Z0006508biological_processproteolysis
a0004176molecular_functionATP-dependent peptidase activity
a0004252molecular_functionserine-type endopeptidase activity
a0005515molecular_functionprotein binding
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0005886cellular_componentplasma membrane
a0006508biological_processproteolysis
a0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
a0008236molecular_functionserine-type peptidase activity
a0009274cellular_componentpeptidoglycan-based cell wall
a0009368cellular_componentendopeptidase Clp complex
a0051117molecular_functionATPase binding
b0004176molecular_functionATP-dependent peptidase activity
b0004252molecular_functionserine-type endopeptidase activity
b0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00381
Number of Residues12
DetailsCLP_PROTEASE_SER Endopeptidase Clp serine active site. TvcLGqAASAAA
ChainResidueDetails
ATHR102-ALA113

site_idPS00382
Number of Residues14
DetailsCLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyalPharILMHQP
ChainResidueDetails
GARG112-PRO125
AARG124-PRO137

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00444
ChainResidueDetails
BSER98
YSER98
NSER98
ZSER98
GSER98
bSER98
PSER98
DSER98
RSER98
ISER98
USER98
KSER98
WSER98
MSER98

site_idSWS_FT_FI2
Number of Residues14
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00444
ChainResidueDetails
BHIS123
YHIS123
NHIS123
ZHIS123
GHIS123
bHIS123
PHIS123
DHIS123
RHIS123
IHIS123
UHIS123
KHIS123
WHIS123
MHIS123

226707

PDB entries from 2024-10-30

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