7X11

Crystal structure of ME1 in complex with NADPH

Summary for 7X11

Entry DOI	10.2210/pdb7x11/pdb
Descriptor	NADP-dependent malic enzyme, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	malic enzyme, complex, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	261961.21
Authors	Amano, Y. (deposition date: 2022-02-22, release date: 2022-07-20, Last modification date: 2023-11-29)
Primary citation	Yoshida, T.,Kawabe, T.,Cantley, L.C.,Lyssiotis, C.A. Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP + -Dependent Malic Enzyme 1. Biochemistry, 61:1548-1553, 2022 Cited by PubMed: 35819845 DOI: 10.1021/acs.biochem.2c00123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation