7X11

Crystal structure of ME1 in complex with NADPH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	NADP-dependent malic enzyme	polymer	572	64223.4	4	UniProt (P48163) Pfam (PF00390) Pfam (PF03949)	Homo sapiens (human)	NADP-ME,Malic enzyme 1
2	E, H, K, N (A, B, C, D)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	F, I, L, O (A, B, C, D)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	4	Chemie (NDP)
4	G, J, M, P (A, B, C, D)	6-[(7-methyl-2-propyl-imidazo[4,5-b]pyridin-4-yl)methyl]-2-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]-1,3-benzothiazole	non-polymer		466.6	4	Chemie (86I)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	602	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	256893.5
Non-Polymers*	Number of molecules	12
	Total formula weight	5067.7
All*	Total formula weight	261961.2

*Water molecules are not included.