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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7X11

Crystal structure of ME1 in complex with NADPH

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004470molecular_functionmalic enzyme activity
A0004473molecular_functionmalate dehydrogenase (decarboxylating) (NADP+) activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006108biological_processmalate metabolic process
A0006739biological_processNADP+ metabolic process
A0008948molecular_functionoxaloacetate decarboxylase activity
A0009055molecular_functionelectron transfer activity
A0009165biological_processnucleotide biosynthetic process
A0009725biological_processresponse to hormone
A0009743biological_processresponse to carbohydrate
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019674biological_processNAD+ metabolic process
A0030145molecular_functionmanganese ion binding
A0042802molecular_functionidentical protein binding
A0043531molecular_functionADP binding
A0046872molecular_functionmetal ion binding
A0050661molecular_functionNADP binding
A0051287molecular_functionNAD binding
A0051289biological_processprotein homotetramerization
A1902031biological_processregulation of NADP metabolic process
B0000287molecular_functionmagnesium ion binding
B0004470molecular_functionmalic enzyme activity
B0004473molecular_functionmalate dehydrogenase (decarboxylating) (NADP+) activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006108biological_processmalate metabolic process
B0006739biological_processNADP+ metabolic process
B0008948molecular_functionoxaloacetate decarboxylase activity
B0009055molecular_functionelectron transfer activity
B0009165biological_processnucleotide biosynthetic process
B0009725biological_processresponse to hormone
B0009743biological_processresponse to carbohydrate
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019674biological_processNAD+ metabolic process
B0030145molecular_functionmanganese ion binding
B0042802molecular_functionidentical protein binding
B0043531molecular_functionADP binding
B0046872molecular_functionmetal ion binding
B0050661molecular_functionNADP binding
B0051287molecular_functionNAD binding
B0051289biological_processprotein homotetramerization
B1902031biological_processregulation of NADP metabolic process
C0000287molecular_functionmagnesium ion binding
C0004470molecular_functionmalic enzyme activity
C0004473molecular_functionmalate dehydrogenase (decarboxylating) (NADP+) activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0006108biological_processmalate metabolic process
C0006739biological_processNADP+ metabolic process
C0008948molecular_functionoxaloacetate decarboxylase activity
C0009055molecular_functionelectron transfer activity
C0009165biological_processnucleotide biosynthetic process
C0009725biological_processresponse to hormone
C0009743biological_processresponse to carbohydrate
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0019674biological_processNAD+ metabolic process
C0030145molecular_functionmanganese ion binding
C0042802molecular_functionidentical protein binding
C0043531molecular_functionADP binding
C0046872molecular_functionmetal ion binding
C0050661molecular_functionNADP binding
C0051287molecular_functionNAD binding
C0051289biological_processprotein homotetramerization
C1902031biological_processregulation of NADP metabolic process
D0000287molecular_functionmagnesium ion binding
D0004470molecular_functionmalic enzyme activity
D0004473molecular_functionmalate dehydrogenase (decarboxylating) (NADP+) activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0006108biological_processmalate metabolic process
D0006739biological_processNADP+ metabolic process
D0008948molecular_functionoxaloacetate decarboxylase activity
D0009055molecular_functionelectron transfer activity
D0009165biological_processnucleotide biosynthetic process
D0009725biological_processresponse to hormone
D0009743biological_processresponse to carbohydrate
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0019674biological_processNAD+ metabolic process
D0030145molecular_functionmanganese ion binding
D0042802molecular_functionidentical protein binding
D0043531molecular_functionADP binding
D0046872molecular_functionmetal ion binding
D0050661molecular_functionNADP binding
D0051287molecular_functionNAD binding
D0051289biological_processprotein homotetramerization
D1902031biological_processregulation of NADP metabolic process
Functional Information from PROSITE/UniProt
site_idPS00331
Number of Residues17
DetailsMALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVaVAGLL
ChainResidueDetails
APHE276-LEU292
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P23368","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P23368","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P23368","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsSite: {"description":"Important for activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06801","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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