7WPQ
Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 3.27 angstron resolution (2 units)
Summary for 7WPQ
Entry DOI | 10.2210/pdb7wpq/pdb |
Related | 7WN4 7WN6 7WPP 7WQT |
EMDB information | 32621 32622 32687 32688 32691 32692 32713 |
Descriptor | von Willebrand antigen 2, von Willebrand factor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | blood, vwf, von willebrand factor, von willebrand disease, blood coagulation, blood clotting, multimer assembly, vwf assembly, d'd3 domain, d1d2 domain, d'd3 dimer, d1d2 dimer, vwf tube, repeating unit |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 547707.46 |
Authors | Zeng, J.W.,Shu, Z.M.,Zhou, A.W. (deposition date: 2022-01-24, release date: 2022-05-25, Last modification date: 2022-06-15) |
Primary citation | Zeng, J.,Shu, Z.,Liang, Q.,Zhang, J.,Wu, W.,Wang, X.,Zhou, A. Structural basis of von Willebrand factor multimerization and tubular storage. Blood, 139:3314-3324, 2022 Cited by PubMed: 35148377DOI: 10.1182/blood.2021014729 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.267 Å) |
Structure validation
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