7UUN
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with neomycin
Summary for 7UUN
Entry DOI | 10.2210/pdb7uun/pdb |
Related | 7UUJ 7UUK 7UUL 7UUM 7UUO |
Descriptor | Aminocyclitol acetyltransferase ApmA, NEOMYCIN, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 32001.03 |
Authors | Stogios, P.J.,Evdokimova, E.,Di Leo, R.,Osipiuk, J.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID),Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-04-28, release date: 2022-11-02, Last modification date: 2024-02-14) |
Primary citation | Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D. Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. Nat.Chem.Biol., 20:234-242, 2024 Cited by PubMed: 37973888DOI: 10.1038/s41589-023-01483-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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