7USD

Cryo-EM structure of D-site Rac1-bound WAVE Regulatory Complex

Summary for 7USD

• Entry DOI: 10.2210/pdb7usd/pdb
• EMDB information: 26733
• Descriptor: Cytoplasmic FMR1-interacting protein 1, Nck-associated protein 1, Wiskott-Aldrich syndrome protein family member 1, ... (8 entities in total)
• Functional Keywords: actin regulator, gtpase binding protein, cytoskeletal regulator, cell invasion
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 359670.25

Authors

Ding, B.,Yang, S.,Chen, B.,Chowdhury, S. (deposition date: 2022-04-25, release date: 2022-09-21, Last modification date: 2024-06-12)

• Primary citation: Ding, B.,Yang, S.,Schaks, M.,Liu, Y.,Brown, A.J.,Rottner, K.,Chowdhury, S.,Chen, B.; Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.; Nat Commun, 13:5444-5444, 2022; PubMed: 36114192; DOI: 10.1038/s41467-022-33174-3

Experimental method

ELECTRON MICROSCOPY (3 Å)