7UJV

Structure of PHD2 in complex with HIF2a-CODD

Summary for 7UJV

Entry DOI	10.2210/pdb7ujv/pdb
Descriptor	Egl nine homolog 1, Endothelial PAS domain-containing protein 1, N-OXALYLGLYCINE, ... (6 entities in total)
Functional Keywords	hif-prolyl-hydroxylase, complex, oxygen-sensing, psuedohypoxic-disease, oxidoreductase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	30416.15
Authors	Ferens, F.G.,Tarade, D.,Lee, J.E.,Ohh, M. (deposition date: 2022-03-31, release date: 2023-04-05, Last modification date: 2024-03-13)
Primary citation	Ferens, F.G.,Taber, C.C.,Stuart, S.,Hubert, M.,Tarade, D.,Lee, J.E.,Ohh, M. Deficiency in PHD2-mediated hydroxylation of HIF2 alpha underlies Pacak-Zhuang syndrome. Commun Biol, 7:240-240, 2024 Cited by PubMed: 38418569 DOI: 10.1038/s42003-024-05904-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation