7UJV
Structure of PHD2 in complex with HIF2a-CODD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Egl nine homolog 1 | polymer | 250 | 27813.6 | 1 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
| 2 | B (A) | Endothelial PAS domain-containing protein 1 | polymer | 21 | 2307.6 | 1 | UniProt (Q99814) Pfam (PF11413) | Homo sapiens | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
| 3 | C (B) | N-OXALYLGLYCINE | non-polymer | 147.1 | 1 | Chemie (OGA) | |||
| 4 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (B) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 6 | F, G (B, A) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
B: 181 - 426 (UniProt: Q9GZT9)
A: 523 - 542 (UniProt: Q99814)
| PDB | External Database | Details |
|---|---|---|
| Gly 177 | - | expression tag |
| Ser 178 | - | expression tag |
| Gly 179 | - | expression tag |
| Ser 180 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Nh2 543 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30121.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 295.0 | |
| All* | Total formula weight | 30416.2 |
