7TZG

Structure of human LAG3 in complex with antibody single-chain variable fragment

Summary for 7TZG

• Entry DOI: 10.2210/pdb7tzg/pdb
• Descriptor: scFvF7, Lymphocyte activation gene 3 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: immune checkpoint, t cell, complex, antibody, ig-like fold, immunosuppressant
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 141842.13

Authors

Ming, Q.,Tran, T.H.,Luca, V.C. (deposition date: 2022-02-15, release date: 2022-05-11, Last modification date: 2023-10-18)

• Primary citation: Ming, Q.,Celias, D.P.,Wu, C.,Cole, A.R.,Singh, S.,Mason, C.,Dong, S.,Tran, T.H.,Amarasinghe, G.K.,Ruffell, B.,Luca, V.C.; LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.; Nat.Immunol., 23:1031-1041, 2022; PubMed: 35761082; DOI: 10.1038/s41590-022-01238-7

Experimental method

X-RAY DIFFRACTION (3.71 Å)