7TXT

Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl

Summary for 7TXT

Entry DOI	10.2210/pdb7txt/pdb
EMDB information	26160
Descriptor	15B8 Fab heavy chain, 15B8 Fab light chain, Sodium-dependent serotonin transporter, ... (4 entities in total)
Functional Keywords	neurotransmitter transporter, small molecule, membrane protein, transport protein
Biological source	Mus musculus More
Total number of polymer chains	3
Total formula weight	86397.45
Authors	Singh, I.,Seth, A.,Billesboelle, C.B.,Braz, J.,Rodriguiz, R.M.,Roy, K.,Bekele, B.,Craik, V.,Huang, X.P.,Boytsov, D.,Lak, P.,O'Donnell, H.,Sandtner, W.,Roth, B.L.,Basbaum, A.I.,Wetsel, W.C.,Manglik, A.,Shoichet, B.K.,Rudnick, G. (deposition date: 2022-02-09, release date: 2023-03-15, Last modification date: 2024-03-27)
Primary citation	Singh, I.,Seth, A.,Billesbolle, C.B.,Braz, J.,Rodriguiz, R.M.,Roy, K.,Bekele, B.,Craik, V.,Huang, X.P.,Boytsov, D.,Pogorelov, V.M.,Lak, P.,O'Donnell, H.,Sandtner, W.,Irwin, J.J.,Roth, B.L.,Basbaum, A.I.,Wetsel, W.C.,Manglik, A.,Shoichet, B.K.,Rudnick, G. Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Cell, 186:2160-2175.e17, 2023 Cited by PubMed: 37137306 DOI: 10.1016/j.cell.2023.04.010 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation