7TXT
Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| S | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYicyqNGGGaF |
| Chain | Residue | Details |
| S | TRP103-PHE117 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLisSFTdqLPWtsCknswNT |
| Chain | Residue | Details |
| S | TYR186-THR206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | PHE88-ASN112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 158 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| S | GLY113-GLY115 | |
| S | LEU187-SER252 | |
| S | ARG298-GLY324 | |
| S | THR381-THR421 | |
| S | GLY484-GLU494 | |
| S | SER559-SER574 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ALA116-MET135 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 81 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| S | GLU136-GLY160 | |
| S | LYS272-SER277 | |
| S | ALA348-ASP360 | |
| S | GLU444-GLU463 | |
| S | GLY517-ARG538 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ILE161-TYR186 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | TRP253-TRP271 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | GLY278-VAL297 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | VAL325-PHE347 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ALA361-PHE380 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | PHE422-LEU443 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ARG464-PHE483 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | TYR495-TYR516 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ILE539-MET558 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ILE575-TYR595 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6, ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
| Chain | Residue | Details |
| S | GLY94 | |
| S | VAL97 | |
| S | ASP437 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000305|PubMed:27049939, ECO:0000312|PDB:7LIA, ECO:0007744|PDB:5I6X |
| Chain | Residue | Details |
| S | ALA96 | |
| S | SER336 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7MGW |
| Chain | Residue | Details |
| S | ASP98 | |
| S | GLU494 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27049939, ECO:0007744|PDB:5I6X |
| Chain | Residue | Details |
| S | ASN101 | |
| S | ASN368 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6 |
| Chain | Residue | Details |
| S | LEU434 | |
| S | SER438 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA, ECO:0000312|PDB:7MGW |
| Chain | Residue | Details |
| S | THR439 | |
| S | PHE556 | |
| S | SER559 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
| Chain | Residue | Details |
| S | TYR495 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21992875 |
| Chain | Residue | Details |
| S | TYR142 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKG => ECO:0000269|PubMed:17913921 |
| Chain | Residue | Details |
| S | THR276 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| S | ASN208 | |
| S | ASN217 |
