7TVF
Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom
Summary for 7TVF
Entry DOI | 10.2210/pdb7tvf/pdb |
Descriptor | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (12 entities in total) |
Functional Keywords | oncoprotein phosphatase scaffold protein adaptor ras leucine rich repeat, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 249100.53 |
Authors | Bonsor, D.A.,Simanshu, D.K. (deposition date: 2022-02-04, release date: 2022-05-04, Last modification date: 2023-10-18) |
Primary citation | Bonsor, D.A.,Alexander, P.,Snead, K.,Hartig, N.,Drew, M.,Messing, S.,Finci, L.I.,Nissley, D.V.,McCormick, F.,Esposito, D.,Rodriguez-Viciana, P.,Stephen, A.G.,Simanshu, D.K. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat.Struct.Mol.Biol., 29:966-977, 2022 Cited by PubMed: 36175670DOI: 10.1038/s41594-022-00841-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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