7TVF

Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom

7TVF の概要

• エントリーDOI: 10.2210/pdb7tvf/pdb
• 分子名称: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (12 entities in total)
• 機能のキーワード: oncoprotein phosphatase scaffold protein adaptor ras leucine rich repeat, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 249100.53

構造登録者

Bonsor, D.A.,Simanshu, D.K. (登録日: 2022-02-04, 公開日: 2022-05-04, 最終更新日: 2023-10-18)

• 主引用文献: Bonsor, D.A.,Alexander, P.,Snead, K.,Hartig, N.,Drew, M.,Messing, S.,Finci, L.I.,Nissley, D.V.,McCormick, F.,Esposito, D.,Rodriguez-Viciana, P.,Stephen, A.G.,Simanshu, D.K.; Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.; Nat.Struct.Mol.Biol., 29:966-977, 2022; PubMed: 36175670; DOI: 10.1038/s41594-022-00841-4

実験手法

X-RAY DIFFRACTION (2.17 Å)