7TQ1

Crystal structure of adaptive laboratory evolved sulfonamide-resistant Dihydropteroate Synthase (DHPS) from Escherichia coli in complex with 6-hydroxymethylpterin

7TQ1 の概要

• エントリーDOI: 10.2210/pdb7tq1/pdb
• 関連するPDBエントリー: 7S2I 7S2J 7S2K 7S2L 7S2M 8SCD
• 分子名称: Dihydropteroate synthase, 6-HYDROXYMETHYLPTERIN (3 entities in total)
• 機能のキーワード: dhps, dihydropteroate synthase, folp, tim barrel, alpha beta protein, sulfonamides, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, idp98884
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62213.08

構造登録者

Stogios, P.J.,Skarina, T.,Tan, K.,Venkatesan, M.,Fruci, M.,Joachimiak, A.,Savchenko, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2022-01-26, 公開日: 2023-05-03, 最終更新日: 2023-10-25)

• 主引用文献: Venkatesan, M.,Fruci, M.,Verellen, L.A.,Skarina, T.,Mesa, N.,Flick, R.,Pham, C.,Mahadevan, R.,Stogios, P.J.,Savchenko, A.; Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.; Nat Commun, 14:4031-4031, 2023; PubMed: 37419898; DOI: 10.1038/s41467-023-39778-7

実験手法

X-RAY DIFFRACTION (2.73 Å)