7TQ1

Crystal structure of adaptive laboratory evolved sulfonamide-resistant Dihydropteroate Synthase (DHPS) from Escherichia coli in complex with 6-hydroxymethylpterin

Summary for 7TQ1

• Entry DOI: 10.2210/pdb7tq1/pdb
• Related: 7S2I 7S2J 7S2K 7S2L 7S2M 8SCD
• Descriptor: Dihydropteroate synthase, 6-HYDROXYMETHYLPTERIN (3 entities in total)
• Functional Keywords: dhps, dihydropteroate synthase, folp, tim barrel, alpha beta protein, sulfonamides, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, idp98884
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 62213.08

Authors

Stogios, P.J.,Skarina, T.,Tan, K.,Venkatesan, M.,Fruci, M.,Joachimiak, A.,Savchenko, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2022-01-26, release date: 2023-05-03, Last modification date: 2023-10-25)

• Primary citation: Venkatesan, M.,Fruci, M.,Verellen, L.A.,Skarina, T.,Mesa, N.,Flick, R.,Pham, C.,Mahadevan, R.,Stogios, P.J.,Savchenko, A.; Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.; Nat Commun, 14:4031-4031, 2023; PubMed: 37419898; DOI: 10.1038/s41467-023-39778-7

Experimental method

X-RAY DIFFRACTION (2.73 Å)