7TQ1
Crystal structure of adaptive laboratory evolved sulfonamide-resistant Dihydropteroate Synthase (DHPS) from Escherichia coli in complex with 6-hydroxymethylpterin
Summary for 7TQ1
Entry DOI | 10.2210/pdb7tq1/pdb |
Related | 7S2I 7S2J 7S2K 7S2L 7S2M 8SCD |
Descriptor | Dihydropteroate synthase, 6-HYDROXYMETHYLPTERIN (3 entities in total) |
Functional Keywords | dhps, dihydropteroate synthase, folp, tim barrel, alpha beta protein, sulfonamides, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, idp98884 |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 62213.08 |
Authors | Stogios, P.J.,Skarina, T.,Tan, K.,Venkatesan, M.,Fruci, M.,Joachimiak, A.,Savchenko, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2022-01-26, release date: 2023-05-03, Last modification date: 2023-10-25) |
Primary citation | Venkatesan, M.,Fruci, M.,Verellen, L.A.,Skarina, T.,Mesa, N.,Flick, R.,Pham, C.,Mahadevan, R.,Stogios, P.J.,Savchenko, A. Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14:4031-4031, 2023 Cited by PubMed: 37419898DOI: 10.1038/s41467-023-39778-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
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