7TE7

Estrogen Receptor Alpha Ligand Binding Domain in Complex with RAD1901

Summary for 7TE7

Entry DOI	10.2210/pdb7te7/pdb
Descriptor	Estrogen receptor, (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol (3 entities in total)
Functional Keywords	estrogen receptor, breast cancer, hormone therapy, alpha helical bundle, transcription factor, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	28813.84
Authors	Joiner, C.,Hancock, G.,Young, K.,Hosfield, D.J.,Greene, G.L.,Fanning, S.W. (deposition date: 2022-01-04, release date: 2022-01-19, Last modification date: 2023-10-25)
Primary citation	Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildiz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W. Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ Breast Cancer, 8:130-130, 2022 Cited by PubMed: 36517522 DOI: 10.1038/s41523-022-00497-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation