7TE7
Estrogen Receptor Alpha Ligand Binding Domain in Complex with RAD1901
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Estrogen receptor | polymer | 249 | 28355.2 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A | (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | non-polymer | 458.6 | 1 | Chemie (I0V) | |||
| 3 | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A: 306 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28355.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 458.6 | |
| All* | Total formula weight | 28813.8 |
