7SXJ
BIO-2895 (BRD0705) bound GSK3beta-axin complex
Summary for 7SXJ
Entry DOI | 10.2210/pdb7sxj/pdb |
Descriptor | Glycogen synthase kinase-3 beta, axin peptide, (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, ... (4 entities in total) |
Functional Keywords | kinase, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 42245.43 |
Authors | Chodaparambil, J.V. (deposition date: 2021-11-23, release date: 2023-06-14, Last modification date: 2023-11-15) |
Primary citation | Amaral, B.,Capacci, A.,Anderson, T.,Tezer, C.,Bajrami, B.,Lulla, M.,Lucas, B.,Chodaparambil, J.V.,Marcotte, D.,Kumar, P.R.,Murugan, P.,Spilker, K.,Cullivan, M.,Wang, T.,Peterson, A.C.,Enyedy, I.,Ma, B.,Chen, T.,Yousaf, Z.,Calhoun, M.,Golonzhka, O.,Dillon, G.M.,Koirala, S. Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors. Acs Chem Neurosci, 14:1080-1094, 2023 Cited by PubMed: 36812145DOI: 10.1021/acschemneuro.2c00476 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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