7SQL

Crystal structure of human uridine-cytidine kinase 2 complexed with a weak small molecule inhibitor

Summary for 7SQL

Entry DOI	10.2210/pdb7sql/pdb
Descriptor	Uridine-cytidine kinase 2, TRIETHYLENE GLYCOL, GLYCEROL, ... (7 entities in total)
Functional Keywords	kinase, uridine kinase, cytidine kinase, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	114759.47
Authors	Mashayekh, S.,Stunkard, L.M.,Kienle, M.,Mathews, I.I.,Khosla, C. (deposition date: 2021-11-05, release date: 2022-10-12, Last modification date: 2023-10-25)
Primary citation	Mashayekh, S.,Stunkard, L.M.,Kienle, M.,Mathews, I.I.,Khosla, C. Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2). Biochemistry, 61:2261-2266, 2022 Cited by PubMed: 36190114 DOI: 10.1021/acs.biochem.2c00451 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation