7SQL

Crystal structure of human uridine-cytidine kinase 2 complexed with a weak small molecule inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004849	molecular_function	uridine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007631	biological_process	feeding behavior
A	0009224	biological_process	CMP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042802	molecular_function	identical protein binding
A	0043771	molecular_function	cytidine kinase activity
A	0044206	biological_process	UMP salvage
A	0044211	biological_process	CTP salvage
A	0048678	biological_process	response to axon injury
A	0071453	biological_process	cellular response to oxygen levels
B	0000166	molecular_function	nucleotide binding
B	0004849	molecular_function	uridine kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007631	biological_process	feeding behavior
B	0009224	biological_process	CMP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042802	molecular_function	identical protein binding
B	0043771	molecular_function	cytidine kinase activity
B	0044206	biological_process	UMP salvage
B	0044211	biological_process	CTP salvage
B	0048678	biological_process	response to axon injury
B	0071453	biological_process	cellular response to oxygen levels
C	0000166	molecular_function	nucleotide binding
C	0004849	molecular_function	uridine kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007631	biological_process	feeding behavior
C	0009224	biological_process	CMP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0042802	molecular_function	identical protein binding
C	0043771	molecular_function	cytidine kinase activity
C	0044206	biological_process	UMP salvage
C	0044211	biological_process	CTP salvage
C	0048678	biological_process	response to axon injury
C	0071453	biological_process	cellular response to oxygen levels
D	0000166	molecular_function	nucleotide binding
D	0004849	molecular_function	uridine kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007631	biological_process	feeding behavior
D	0009224	biological_process	CMP biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0042802	molecular_function	identical protein binding
D	0043771	molecular_function	cytidine kinase activity
D	0044206	biological_process	UMP salvage
D	0044211	biological_process	CTP salvage
D	0048678	biological_process	response to axon injury
D	0071453	biological_process	cellular response to oxygen levels

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:15130468, ECO:0000269|PubMed:15735337

Chain	Residue	Details
A	GLY27
B	ASP84
B	TYR112
B	HIS117
B	ARG166
B	ARG176
B	GLN184
B	ASP213
C	GLY27
C	ASP84
C	TYR112
A	ASP84
C	HIS117
C	ARG166
C	ARG176
C	GLN184
C	ASP213
D	GLY27
D	ASP84
D	TYR112
D	HIS117
D	ARG166
A	TYR112
D	ARG176
D	GLN184
D	ASP213
A	HIS117
A	ARG166
A	ARG176
A	GLN184
A	ASP213
B	GLY27

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2

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