7SQL
Crystal structure of human uridine-cytidine kinase 2 complexed with a weak small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004849 | molecular_function | uridine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005575 | cellular_component | cellular_component |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009224 | biological_process | CMP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043771 | molecular_function | cytidine kinase activity |
| A | 0044206 | biological_process | UMP salvage |
| A | 0044211 | biological_process | CTP salvage |
| B | 0004849 | molecular_function | uridine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005575 | cellular_component | cellular_component |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009224 | biological_process | CMP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043771 | molecular_function | cytidine kinase activity |
| B | 0044206 | biological_process | UMP salvage |
| B | 0044211 | biological_process | CTP salvage |
| C | 0004849 | molecular_function | uridine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005575 | cellular_component | cellular_component |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009224 | biological_process | CMP biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043771 | molecular_function | cytidine kinase activity |
| C | 0044206 | biological_process | UMP salvage |
| C | 0044211 | biological_process | CTP salvage |
| D | 0004849 | molecular_function | uridine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005575 | cellular_component | cellular_component |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009224 | biological_process | CMP biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043771 | molecular_function | cytidine kinase activity |
| D | 0044206 | biological_process | UMP salvage |
| D | 0044211 | biological_process | CTP salvage |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15130468, ECO:0000269|PubMed:15735337 |
| Chain | Residue | Details |
| A | GLY27 | |
| B | ASP84 | |
| B | TYR112 | |
| B | HIS117 | |
| B | ARG166 | |
| B | ARG176 | |
| B | GLN184 | |
| B | ASP213 | |
| C | GLY27 | |
| C | ASP84 | |
| C | TYR112 | |
| A | ASP84 | |
| C | HIS117 | |
| C | ARG166 | |
| C | ARG176 | |
| C | GLN184 | |
| C | ASP213 | |
| D | GLY27 | |
| D | ASP84 | |
| D | TYR112 | |
| D | HIS117 | |
| D | ARG166 | |
| A | TYR112 | |
| D | ARG176 | |
| D | GLN184 | |
| D | ASP213 | |
| A | HIS117 | |
| A | ARG166 | |
| A | ARG176 | |
| A | GLN184 | |
| A | ASP213 | |
| B | GLY27 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
