7SOL

Crystal Structures of the bispecific ubiquitin/FAT10 activating enzyme, Uba6

7SOL の概要

• エントリーDOI: 10.2210/pdb7sol/pdb
• 分子名称: Ubiquitin-like modifier-activating enzyme 6, Ubiquitin, INOSITOL HEXAKISPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: ubiquitin, e1, adenylation, thioester bond, e2, fat10, ip6, ligase, atp-binding, nucleotide binding, conformational change, signaling protein, signaling protein-ligase complex, signaling protein/ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 250260.69

構造登録者

Olsen, S.K.,Gao, F.,Lv, Z. (登録日: 2021-10-31, 公開日: 2022-11-02, 最終更新日: 2024-04-17)

• 主引用文献: Yuan, L.,Gao, F.,Lv, Z.,Nayak, D.,Nayak, A.,Santos Bury, P.D.,Cano, K.E.,Jia, L.,Oleinik, N.,Atilgan, F.C.,Ogretmen, B.,Williams, K.M.,Davies, C.,El Oualid, F.,Wasmuth, E.V.,Olsen, S.K.; Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.; Nat Commun, 13:4880-4880, 2022; PubMed: 35986001; DOI: 10.1038/s41467-022-32613-5

実験手法

X-RAY DIFFRACTION (2.25000635563 Å)