7S87

Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01

Summary for 7S87

• Entry DOI: 10.2210/pdb7s87/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, (4R)-3-methyl-5-[(4R)-4-methyl-3,4-dihydroisoquinolin-2(1H)-yl]thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine, FLAVIN MONONUCLEOTIDE, ... (8 entities in total)
• Functional Keywords: inhibitor, dhodh, tim barrel, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 2
• Total formula weight: 94252.39

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-09-17, release date: 2021-09-29, Last modification date: 2023-10-18)

• Primary citation: Seattle Structural Genomics Center for Infectious Disease (SSGCID),Shek, R.,Abendroth, J.,Lorimer, D.,Edwards, T.E.,Eastman, R.,Van Voorhis, W.; Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)