7S87
Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 401 | 45385.9 | 2 | UniProt (Q08210) Pfam (PF01180) In PDB | Plasmodium falciparum (isolate 3D7) | DHOdehase,Dihydroorotate oxidase |
2 | A, B | (4R)-3-methyl-5-[(4R)-4-methyl-3,4-dihydroisoquinolin-2(1H)-yl]thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine | non-polymer | 335.4 | 4 | Chemie (8IE) | |||
3 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
4 | A, B | OROTIC ACID | non-polymer | 156.1 | 2 | Chemie (ORO) | |||
5 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
6 | A | polyethylene glycol | non-polymer | 662.8 | 1 | Chemie (P4K) | |||
7 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
8 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B: 158 - 539 (UniProt: Q08210)
PDB | External Database | Details |
---|---|---|
Met 139 | - | initiating methionine |
Gly 140 | - | expression tag |
His 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
His 144 | - | expression tag |
His 145 | - | expression tag |
His 146 | - | expression tag |
Ala 147 | - | expression tag |
Glu 148 | - | expression tag |
Asn 149 | - | expression tag |
Leu 150 | - | expression tag |
Tyr 151 | - | expression tag |
Phe 152 | - | expression tag |
Gln 153 | - | expression tag |
Gly 154 | - | expression tag |
Ala 155 | - | expression tag |
Asp 156 | - | expression tag |
Pro 157 | - | expression tag |
- | Ser 384 | deletion |
- | Thr 385 | deletion |
- | Tyr 386 | deletion |
- | Asn 387 | deletion |
- | Glu 388 | deletion |
- | Asp 389 | deletion |
- | Asn 390 | deletion |
- | Lys 391 | deletion |
- | Ile 392 | deletion |
- | Val 393 | deletion |
- | Glu 394 | deletion |
- | Lys 395 | deletion |
- | Lys 396 | deletion |
- | Asn 397 | deletion |
- | Asn 398 | deletion |
- | Phe 399 | deletion |
- | Asn 400 | deletion |
- | Lys 401 | deletion |
- | Asn 402 | deletion |
- | Asn 403 | deletion |
- | Ser 404 | deletion |
- | His 405 | deletion |
- | Met 406 | deletion |
- | Met 407 | deletion |
- | Lys 408 | deletion |
- | Asp 409 | deletion |
- | Ala 410 | deletion |
- | Lys 411 | deletion |
- | Asp 412 | deletion |
- | Asn 413 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 90771.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 3480.6 | |
All* | Total formula weight | 94252.4 |