7S15

GLP-1 receptor bound with Pfizer small molecule agonist

Summary for 7S15

• Entry DOI: 10.2210/pdb7s15/pdb
• EMDB information: 24794
• Descriptor: Glucagon-like peptide 1 receptor, 2-[(4-{6-[(2,4-difluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid (2 entities in total)
• Functional Keywords: glp-1r, gpcr, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 47287.64

Authors

Liu, Y.,Dias, J.M.,Han, S. (deposition date: 2021-09-01, release date: 2022-06-08, Last modification date: 2022-07-06)

• Primary citation: Griffith, D.A.,Edmonds, D.J.,Fortin, J.P.,Kalgutkar, A.S.,Kuzmiski, J.B.,Loria, P.M.,Saxena, A.R.,Bagley, S.W.,Buckeridge, C.,Curto, J.M.,Derksen, D.R.,Dias, J.M.,Griffor, M.C.,Han, S.,Jackson, V.M.,Landis, M.S.,Lettiere, D.,Limberakis, C.,Liu, Y.,Mathiowetz, A.M.,Patel, J.C.,Piotrowski, D.W.,Price, D.A.,Ruggeri, R.B.,Tess, D.A.; A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.; J.Med.Chem., 65:8208-8226, 2022; PubMed: 35647711; DOI: 10.1021/acs.jmedchem.1c01856

Experimental method

ELECTRON MICROSCOPY (3.8 Å)