7S15
GLP-1 receptor bound with Pfizer small molecule agonist
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0004888 | molecular_function | transmembrane signaling receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004967 | molecular_function | glucagon receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0007190 | biological_process | activation of adenylate cyclase activity |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0007611 | biological_process | learning or memory |
| R | 0008016 | biological_process | regulation of heart contraction |
| R | 0008528 | molecular_function | G protein-coupled peptide receptor activity |
| R | 0016020 | cellular_component | membrane |
| R | 0017046 | molecular_function | peptide hormone binding |
| R | 0031204 | biological_process | post-translational protein targeting to membrane, translocation |
| R | 0038023 | molecular_function | signaling receptor activity |
| R | 0044508 | molecular_function | glucagon-like peptide 1 receptor activity |
| R | 0045776 | biological_process | negative regulation of blood pressure |
| R | 0045777 | biological_process | positive regulation of blood pressure |
| R | 0046879 | biological_process | hormone secretion |
| R | 0065008 | biological_process | regulation of biological quality |
| R | 0071377 | biological_process | cellular response to glucagon stimulus |
| R | 1990911 | biological_process | response to psychosocial stress |
Functional Information from PROSITE/UniProt
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP |
| Chain | Residue | Details |
| R | CYS62-PRO86 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV |
| Chain | Residue | Details |
| R | GLN394-VAL409 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 51 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Region: {"description":"Important for allosteric inhibitor binding","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with the endogenous ligand GLP-1","evidences":[{"source":"PubMed","id":"19861722","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"21901419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22412906","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
