7S15
GLP-1 receptor bound with Pfizer small molecule agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Glucagon-like peptide 1 receptor | polymer | 399 | 46701.0 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (Human) | GLP-1 receptor,GLP-1-R,GLP-1R |
| 2 | B (R) | 2-[(4-{6-[(2,4-difluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid | non-polymer | 586.6 | 1 | Chemie (82L) |
Sequence modifications
R: 24 - 422 (UniProt: P43220)
| PDB | External Database | Details |
|---|---|---|
| Tyr 146 | Ile 146 | engineered mutation |
| Arg 208 | Ala 208 | engineered mutation |
| Glu 213 | Gln 213 | engineered mutation |
| Arg 219 | Ser 219 | engineered mutation |
| Ala 260 | Leu 260 | engineered mutation |
| Ala 291 | Tyr 291 | engineered mutation |
| Glu 339 | Leu 339 | engineered mutation |
| Gln 346 | Lys 346 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46701.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 586.6 | |
| All* | Total formula weight | 47287.6 |
