7RYC

Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein

7RYC の概要

• エントリーDOI: 10.2210/pdb7ryc/pdb
• EMDBエントリー: 24733
• 分子名称: Oxytocin, Oxytocin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• 機能のキーワード: hormone, gpcr complex, transmembrane receptor, oxytocin receptor, otr, ot, oxtr, g protein, oxytocin, vasotocin, membrane protein, membrane protein-neuropeptide complex, membrane protein/neuropeptide
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 152682.05

構造登録者

Meyerowitz, J.G.,Robertson, M.J.,Skiniotis, G. (登録日: 2021-08-24, 公開日: 2022-03-09, 最終更新日: 2022-03-30)

• 主引用文献: Meyerowitz, J.G.,Robertson, M.J.,Barros-Alvarez, X.,Panova, O.,Nwokonko, R.M.,Gao, Y.,Skiniotis, G.; The oxytocin signaling complex reveals a molecular switch for cation dependence.; Nat.Struct.Mol.Biol., 29:274-281, 2022; PubMed: 35241813; DOI: 10.1038/s41594-022-00728-4

実験手法

ELECTRON MICROSCOPY (2.9 Å)