7QUH

Siglec-8 in complex with therapeutic Fab AK002.

Summary for 7QUH

Entry DOI	10.2210/pdb7quh/pdb
Related	7QU6
Descriptor	Sialic acid-binding immunoglobulin-type lectin, Sialic acid-binding Ig-like lectin 8 (3 entities in total)
Functional Keywords	siglec, sialic acid, antibody, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	85124.81
Authors	Lenza, M.P.,Oyenarte, I.,Jimenez Barbero, J.,Ereno Orbea, J. (deposition date: 2022-01-18, release date: 2023-05-31, Last modification date: 2024-02-07)
Primary citation	Lenza, M.P.,Atxabal, U.,Nycholat, C.,Oyenarte, I.,Franconetti, A.,Quintana, J.I.,Delgado, S.,Nunez-Franco, R.,Garnica Marroquin, C.T.,Coelho, H.,Unione, L.,Jimenez-Oses, G.,Marcelo, F.,Schubert, M.,Paulson, J.C.,Jimenez-Barbero, J.,Ereno-Orbea, J. Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody. Jacs Au, 3:204-215, 2023 Cited by PubMed: 36711084 DOI: 10.1021/jacsau.2c00592 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.867 Å)

Structure validation