7QUH
Siglec-8 in complex with therapeutic Fab AK002.
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR204-HIS210 | |
| H | TYR200-HIS206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27357658, ECO:0007744|PDB:2N7B |
| Chain | Residue | Details |
| A | TYR23 | |
| A | ARG72 | |
| A | ARG125 | |
| A | SER134 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Indispensable role in 6'-sulfo sialyl-Lewis X => ECO:0000269|PubMed:27357658 |
| Chain | Residue | Details |
| A | ARG125 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN172 | |
| A | ASN249 | |
| A | ASN267 |
