7QUH
Siglec-8 in complex with therapeutic Fab AK002.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Sialic acid-binding immunoglobulin-type lectin | polymer | 223 | 23603.4 | 1 | Homo sapiens | ||
| 2 | B (L) | Sialic acid-binding immunoglobulin-type lectin | polymer | 213 | 23203.8 | 1 | Homo sapiens | ||
| 3 | C (A) | Sialic acid-binding Ig-like lectin 8 | polymer | 350 | 38317.7 | 1 | UniProt (Q9NYZ4) Pfam (PF07686) Pfam (PF00047) Pfam (PF13927) | Homo sapiens (human) | Siglec-8,Sialoadhesin family member 2,SAF-2 |
Sequence modifications
A: 17 - 352 (UniProt: Q9NYZ4)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | Cys 42 | conflict |
| Gly 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Val 356 | - | expression tag |
| Pro 357 | - | expression tag |
| Arg 358 | - | expression tag |
| Gly 359 | - | expression tag |
| Ser 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
| His 363 | - | expression tag |
| His 364 | - | expression tag |
| His 365 | - | expression tag |
| His 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 85124.8 | |
| All* | Total formula weight | 85124.8 |
