7QUH

Siglec-8 in complex with therapeutic Fab AK002.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Sialic acid-binding immunoglobulin-type lectin	polymer	223	23603.4	1		Homo sapiens
2	L	Sialic acid-binding immunoglobulin-type lectin	polymer	213	23203.8	1		Homo sapiens
3	A	Sialic acid-binding Ig-like lectin 8	polymer	350	38317.7	1	UniProt (Q9NYZ4) Pfam (PF07686) Pfam (PF00047) Pfam (PF13927) In PDB	Homo sapiens (human)	Siglec-8,Sialoadhesin family member 2,SAF-2

Sequence modifications

A: 17 - 352 (UniProt: Q9NYZ4)

PDB	External Database	Details
Ser 42	Cys 42	conflict
Gly 353	-	expression tag
Ser 354	-	expression tag
Leu 355	-	expression tag
Val 356	-	expression tag
Pro 357	-	expression tag
Arg 358	-	expression tag
Gly 359	-	expression tag
Ser 360	-	expression tag
His 361	-	expression tag
His 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	85124.8
All*	Total formula weight	85124.8

*Water molecules are not included.