7QNW

The receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with Beta-55 and EY6A Fabs

Summary for 7QNW

• Entry DOI: 10.2210/pdb7qnw/pdb
• Descriptor: EY6A heavy chain, EY6A light chain, Surface glycoprotein, ... (10 entities in total)
• Functional Keywords: sars-cov-2, beta variant, omicron variant, b.1.351, b.1.1.529, antibody, rbd, spike, neutralisation, viral protein/immune system, viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 120613.18

Authors

Zhou, D.,Ren, J.,Stuart, D.I. (deposition date: 2021-12-23, release date: 2022-01-19, Last modification date: 2024-01-31)

• Primary citation: Dejnirattisai, W.,Huo, J.,Zhou, D.,Zahradnik, J.,Supasa, P.,Liu, C.,Duyvesteyn, H.M.E.,Ginn, H.M.,Mentzer, A.J.,Tuekprakhon, A.,Nutalai, R.,Wang, B.,Dijokaite, A.,Khan, S.,Avinoam, O.,Bahar, M.,Skelly, D.,Adele, S.,Johnson, S.A.,Amini, A.,Ritter, T.G.,Mason, C.,Dold, C.,Pan, D.,Assadi, S.,Bellass, A.,Omo-Dare, N.,Koeckerling, D.,Flaxman, A.,Jenkin, D.,Aley, P.K.,Voysey, M.,Costa Clemens, S.A.,Naveca, F.G.,Nascimento, V.,Nascimento, F.,Fernandes da Costa, C.,Resende, P.C.,Pauvolid-Correa, A.,Siqueira, M.M.,Baillie, V.,Serafin, N.,Kwatra, G.,Da Silva, K.,Madhi, S.A.,Nunes, M.C.,Malik, T.,Openshaw, P.J.M.,Baillie, J.K.,Semple, M.G.,Townsend, A.R.,Huang, K.A.,Tan, T.K.,Carroll, M.W.,Klenerman, P.,Barnes, E.,Dunachie, S.J.,Constantinides, B.,Webster, H.,Crook, D.,Pollard, A.J.,Lambe, T.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Schreiber, G.,Stuart, D.I.,Screaton, G.R.; SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.; Cell, 185:467-484.e15, 2022; PubMed: 35081335; DOI: 10.1016/j.cell.2021.12.046

Experimental method

X-RAY DIFFRACTION (2.4 Å)