7QNW

The receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with Beta-55 and EY6A Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	EY6A heavy chain	polymer	226	24346.3	1		Homo sapiens (Human)
2	B (L)	EY6A light chain	polymer	215	23315.9	1		Homo sapiens (Human)
3	C (E)	Surface glycoprotein	polymer	202	23157.2	1	UniProt (A0A7U3CI26) Pfam (PF09408) UniProt (by SIFTS) (P0DTC2)	Severe acute respiratory syndrome coronavirus 2
4	D (A)	Beta-55 heavy chain	polymer	232	24895.9	1		Homo sapiens (Human)
5	E (B)	Beta-55 light chain	polymer	215	23491.2	1		Homo sapiens (Human)
6	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	G, H, I, J, L... (L, E, A, B)	GLYCEROL	non-polymer		92.1	9	Chemie (GOL)
8	K, P (E, A)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
9	Q (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
10	S, T, U, V, W (H, L, E, A, B)	water	water		18.0	102	Chemie (HOH)

Sequence modifications

E: 333 - 528 (UniProt: A0A7U3CI26)

PDB	External Database	Details
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Asp 339	Gly 16	variant
Leu 371	Ser 48	variant
Pro 373	Ser 50	variant
Phe 375	Ser 52	variant
Lys 440	Asn 117	conflict
Ser 446	Gly 123	variant
Asn 477	Ser 154	conflict
Lys 478	Thr 155	variant
Ala 484	Lys 161	conflict
Arg 493	Gln 170	conflict
Ser 496	Gly 173	conflict
Arg 498	Gln 175	variant
His 505	Tyr 182	conflict
Lys 527	Pro 204	variant

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	119206.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	12
	Total formula weight	982.4
All*	Total formula weight	120613.2

*Water molecules are not included.