7QDT

Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to model dominant negative human mutations.

7QDT の概要

• エントリーDOI: 10.2210/pdb7qdt/pdb
• 分子名称: Isoform Alpha-1 of Thyroid hormone receptor alpha, 3,5,3'TRIIODOTHYRONINE (3 entities in total)
• 機能のキーワード: nuclear receptor, thyroid hormone, mutation, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27376.87

構造登録者

Romartinez-Alonso, B.,Fairall, L.,Agostini, M.,Chatterjee, K.,Schwabe, J. (登録日: 2021-11-30, 公開日: 2022-01-26, 最終更新日: 2024-01-31)

• 主引用文献: Romartinez-Alonso, B.,Agostini, M.,Jones, H.,McLellan, J.,Sood, D.E.,Tomkinson, N.,Marelli, F.,Gentile, I.,Visser, W.E.,Schoenmakers, E.,Fairall, L.,Privalsky, M.,Moran, C.,Persani, L.,Chatterjee, K.,Schwabe, J.W.R.; Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone alpha.; Mol.Cell.Biol., 42:e0036321-e0036321, 2022; PubMed: 34871063; DOI: 10.1128/MCB.00363-21

実験手法

X-RAY DIFFRACTION (3 Å)