7Q6Z

Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575

7Q6Z の概要

• エントリーDOI: 10.2210/pdb7q6z/pdb
• 関連するPDBエントリー: 7Q1U
• EMDBエントリー: 13764 13860
• 分子名称: Protein-cysteine N-palmitoyltransferase HHAT, Megabody 177, CHOLESTEROL, ... (6 entities in total)
• 機能のキーワード: hhat, inhibitor, palmitoyl-coa, co enzyme a, hedgehog acyl transferase, sonic hedgehog, shh, mboat, morphogen, palmitoylation, signalling, endoplasmic reticulum, membrane protein, heme, small molecule binding, drug target
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 162532.39

構造登録者

Coupland, C.,Carrique, L.,Siebold, C. (登録日: 2021-11-09, 公開日: 2022-01-26)

• 主引用文献: Coupland, C.E.,Andrei, S.A.,Ansell, T.B.,Carrique, L.,Kumar, P.,Sefer, L.,Schwab, R.A.,Byrne, E.F.X.,Pardon, E.,Steyaert, J.,Magee, A.I.,Lanyon-Hogg, T.,Sansom, M.S.P.,Tate, E.W.,Siebold, C.; Structure, mechanism, and inhibition of Hedgehog acyltransferase.; Mol.Cell, 81:5025-5038.e10, 2021; PubMed: 34890564; DOI: 10.1016/j.molcel.2021.11.018

実験手法

ELECTRON MICROSCOPY (3.59 Å)