7Q3P

Crystal structure of IgG1-Fc-MST-HN (efgartigimod)

Summary for 7Q3P

• Entry DOI: 10.2210/pdb7q3p/pdb
• Descriptor: IgG1-Fc-MST-HN, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: fc, igg1-fc-mst-hn, efgartigimod, argx-113, fcrn, fcrn-binding protein, immune system
• Biological source: Homo sapiens
• Total number of polymer chains: 3
• Total formula weight: 81025.70

Authors

Pannecoucke, E.,Savvides, S.N. (deposition date: 2021-10-28, release date: 2022-09-28, Last modification date: 2024-01-31)

• Primary citation: Brinkhaus, M.,Pannecoucke, E.,van der Kooi, E.J.,Bentlage, A.E.H.,Derksen, N.I.L.,Andries, J.,Balbino, B.,Sips, M.,Ulrichts, P.,Verheesen, P.,de Haard, H.,Rispens, T.,Savvides, S.N.,Vidarsson, G.; The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.; Nat Commun, 13:6073-6073, 2022; PubMed: 36241613; DOI: 10.1038/s41467-022-33764-1

Experimental method

X-RAY DIFFRACTION (2.1 Å)