7Q3P

Crystal structure of IgG1-Fc-MST-HN (efgartigimod)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	IgG1-Fc-MST-HN	polymer	225	25492.8	3	Pfam (PF07654) UniProt (by SIFTS) (P01857) In PDB	Homo sapiens
2	D, G	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	2	In PDB GlyTouCan (G86851RC)
3	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G43381RC)
4	F, I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose	branched		383.3	2	In PDB GlyTouCan (G85856KC)
5	H	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		707.6	1	In PDB GlyTouCan (G32791GB)
6	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7	B	beta-D-mannopyranose	non-polymer		180.2	1	Chemie (BMA)
8	B	alpha-D-mannopyranose	non-polymer		180.2	2	Chemie (MAN)
9	B	alpha-L-fucopyranose	non-polymer		164.2	1	Chemie (FUC)
10		water	water		18.0	461	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	76478.5
Branched	Number of molecules	6
	Total formula weight	2957.7
Non-Polymers*	Number of molecules	8
	Total formula weight	1589.5
All*	Total formula weight	81025.7

*Water molecules are not included.