7P8P
Crystal structure of Fhit covalently bound to a nucleotide
Summary for 7P8P
Entry DOI | 10.2210/pdb7p8p/pdb |
Descriptor | Bis(5'-adenosyl)-triphosphatase, [(2~{R},3~{S},4~{R},5~{R})-5-[6-(ethylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, SODIUM ION, ... (5 entities in total) |
Functional Keywords | fhit, ap3a, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 77499.76 |
Authors | Herzog, D.,Missun, M.,Diederichs, K.,Marx, A. (deposition date: 2021-07-23, release date: 2022-06-01, Last modification date: 2024-01-31) |
Primary citation | Herzog, D.,Jansen, J.,Missun, M.,Diederichs, K.,Stengel, F.,Marx, A. Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap 3 A Elucidates Its Inhibitory Action on Translation. J.Am.Chem.Soc., 144:8613-8623, 2022 Cited by PubMed: 35522782DOI: 10.1021/jacs.2c00815 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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