7P8P

Crystal structure of Fhit covalently bound to a nucleotide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Bis(5'-adenosyl)-triphosphatase	polymer	163	18804.3	4	UniProt (P49789) Pfam (PF01230) In PDB	Homo sapiens (Human)	AP3A hydrolase,AP3Aase,Diadenosine 5',5'''-P1,P3-triphosphate hydrolase,Dinucleosidetriphosphatase,Fragile histidine triad protein
2	A, B, C, D	[(2~{R},3~{S},4~{R},5~{R})-5-[6-(ethylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate	non-polymer		522.9	4	Chemie (6BI)
3	A, B	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
4	B	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS)
5		water	water		18.0	78	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 147 (UniProt: P49789)

PDB	External Database	Details
Cys 8	His 8	engineered mutation
Asn 96	His 96	engineered mutation
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
Ala 154	-	expression tag
Ala 155	-	expression tag
Trp 156	-	expression tag
Ser 157	-	expression tag
Gln 158	-	expression tag
Ala 159	-	expression tag
Gln 160	-	expression tag
Phe 161	-	expression tag
Glu 162	-	expression tag
Lys 163	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	75217.1
Non-Polymers*	Number of molecules	8
	Total formula weight	2282.6
All*	Total formula weight	77499.8

*Water molecules are not included.