7OZD
FGFR1 kinase domain (residues 458-765) with mutations C488A, C584S in complex with 34.
This is a non-PDB format compatible entry.
Summary for 7OZD
Entry DOI | 10.2210/pdb7ozd/pdb |
Descriptor | Fibroblast growth factor receptor 1, N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]benzamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | fgfr1, inhibitor, receptor tyrosine kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72008.23 |
Authors | Trinh, C.H.,Turner, L.D.,Fishwick, C.W.G. (deposition date: 2021-06-27, release date: 2021-12-01, Last modification date: 2024-01-31) |
Primary citation | Turner, L.D.,Trinh, C.H.,Hubball, R.A.,Orritt, K.M.,Lin, C.C.,Burns, J.E.,Knowles, M.A.,Fishwick, C.W.G. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J.Med.Chem., 65:1481-1504, 2022 Cited by PubMed: 34780700DOI: 10.1021/acs.jmedchem.1c01163 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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