7OZD
FGFR1 kinase domain (residues 458-765) with mutations C488A, C584S in complex with 34.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (AAA, BBB) | Fibroblast growth factor receptor 1 | polymer | 309 | 35135.3 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | C, L (AAA, BBB) | N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]benzamide | non-polymer | 329.4 | 2 | Chemie (42I) | |||
| 3 | D, E, F, G, H... (AAA, BBB) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 4 | I, J, K, P, Q (AAA, BBB) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | R, S (AAA, BBB) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
AAA, BBB: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 457 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70270.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1737.5 | |
| All* | Total formula weight | 72008.2 |
