7OS4
Crystal structure of mouse CARM1 in complex with histone H3_13-31 K18
Summary for 7OS4
Entry DOI | 10.2210/pdb7os4/pdb |
Descriptor | Histone-arginine methyltransferase CARM1, Histone H3.1, (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, ... (4 entities in total) |
Functional Keywords | protein arginine n-methyltransferase, prmt, carm1, transition state mimics, transcription |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 8 |
Total formula weight | 176981.17 |
Authors | Marechal, N.,Cura, V.,Troffer-Charlier, N.,Bonnefond, L.,Cavarelli, J. (deposition date: 2021-06-07, release date: 2021-10-27, Last modification date: 2024-01-31) |
Primary citation | Zhang, Y.,Marechal, N.,van Haren, M.J.,Troffer-Charlier, N.,Cura, V.,Cavarelli, J.,Martin, N.I. Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors. Chembiochem, 22:3469-3476, 2021 Cited by PubMed: 34569136DOI: 10.1002/cbic.202100506 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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