7O9W

Encequidar-bound human P-glycoprotein in complex with UIC2-Fab

Summary for 7O9W

Entry DOI	10.2210/pdb7o9w/pdb
EMDB information	12765
Descriptor	Multidrug resistance protein 1, UIC2 Fab-fragment light chain, UIC2 Fab-fragment heavy chain, ... (4 entities in total)
Functional Keywords	abcb1, mdr1, p-glycoprotein, nanodisc, encequidar, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	191712.59
Authors	Nosol, K.,Locher, K.P. (deposition date: 2021-04-17, release date: 2022-01-12, Last modification date: 2022-01-26)
Primary citation	Urgaonkar, S.,Nosol, K.,Said, A.M.,Nasief, N.N.,Bu, Y.,Locher, K.P.,Lau, J.Y.N.,Smolinski, M.P. Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations. J.Med.Chem., 65:191-216, 2022 Cited by PubMed: 34928144 DOI: 10.1021/acs.jmedchem.1c01272 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation