7NTU
X-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: NU172 and HD22_27mer
Summary for 7NTU
Entry DOI | 10.2210/pdb7ntu/pdb |
Related PRD ID | PRD_000020 |
Descriptor | Prothrombin, NU172, HD22_27mer, ... (8 entities in total) |
Functional Keywords | ternary complex, anticoagulant aptamers, duplex/quadruplex, coagulation factor, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 102511.16 |
Authors | Troisi, R.,Santamaria, A.,Sica, F. (deposition date: 2021-03-10, release date: 2021-04-28, Last modification date: 2024-10-16) |
Primary citation | Troisi, R.,Balasco, N.,Santamaria, A.,Vitagliano, L.,Sica, F. Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human alpha-thrombin. Int.J.Biol.Macromol., 181:858-867, 2021 Cited by PubMed: 33864869DOI: 10.1016/j.ijbiomac.2021.04.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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