7NE6

Human TET2 in complex with unfavourable DNA substrate.

Summary for 7NE6

• Entry DOI: 10.2210/pdb7ne6/pdb
• Descriptor: Methylcytosine dioxygenase TET2, DNA (5'-D(*AP*CP*AP*GP*GP*(5CM)P*GP*CP*CP*TP*G)-3'), ZINC ION, ... (8 entities in total)
• Functional Keywords: dna binding, complex, iron dependent dioxygenase, tet2, dna modification, epigenetics, 5-methylcytosine, ion binding, iron binding protein, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 59464.79

Authors

Rafalski, D.,Bochtler, M. (deposition date: 2021-02-03, release date: 2022-03-02, Last modification date: 2024-01-31)

• Primary citation: Ravichandran, M.,Rafalski, D.,Davies, C.I.,Ortega-Recalde, O.,Nan, X.,Glanfield, C.R.,Kotter, A.,Misztal, K.,Wang, A.H.,Wojciechowski, M.,Razew, M.,Mayyas, I.M.,Kardailsky, O.,Schwartz, U.,Zembrzycki, K.,Morison, I.M.,Helm, M.,Weichenhan, D.,Jurkowska, R.Z.,Krueger, F.,Plass, C.,Zacharias, M.,Bochtler, M.,Hore, T.A.,Jurkowski, T.P.; Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.; Sci Adv, 8:eabm2427-eabm2427, 2022; PubMed: 36070377; DOI: 10.1126/sciadv.abm2427

Experimental method

X-RAY DIFFRACTION (2.3 Å)